Diabetic ketoacidosis and hyperosmolar hyperglycemic nonketotic coma

Med Clin North Am. 1988 Nov;72(6):1545-63. doi: 10.1016/s0025-7125(16)30721-0.


Diabetic ketoacidosis and hyperosmolar hyperglycemic nonketotic coma are two of the most common acute complications of diabetes. The pathophysiologic changes that occur in both disease states represent an extreme example of the super-fasted state. The physiology of the fed and fasted state, evaluation, therapeutic issues, recommendations for therapy, immediate follow up care, and complications of therapy are reviewed for both syndromes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Diabetic Coma* / drug therapy
  • Diabetic Coma* / etiology
  • Diabetic Coma* / physiopathology
  • Diabetic Ketoacidosis* / drug therapy
  • Diabetic Ketoacidosis* / etiology
  • Diabetic Ketoacidosis* / physiopathology
  • Fasting
  • Humans
  • Hyperglycemic Hyperosmolar Nonketotic Coma* / drug therapy
  • Hyperglycemic Hyperosmolar Nonketotic Coma* / etiology
  • Hyperglycemic Hyperosmolar Nonketotic Coma* / physiopathology
  • Risk Factors