Recovery of the Ellipsoid and Interdigitation Zones in Acute Behcet's Uveitis after Therapy

Ocul Immunol Inflamm. 2020 Oct 2;28(7):1129-1132. doi: 10.1080/09273948.2019.1644351. Epub 2019 Aug 16.

Abstract

Purpose: To report acute photoreceptor layers loss in Behcet's disease and its anatomical recovery after treatment with systemic steroids, mycophenolate mofetil, and adalimumab. Methods: Case report. Results: A 16-year-old male who presented with an acute attack of Behcet's panuveitis along with loss of the ellipsoid zone (EZ) and interdigitation zone (IZ) on optical coherence tomography (OCT). Treatment resulted in complete recovery of photoreceptors and improvement in vision. Conclusion: Acute photoreceptor layers loss could be a manifestation of Behcet's uveitis and anatomical recovery may be achieved with aggressive and timely treatment.

Keywords: Behcet’s disease; ellipsoid zone; photoreceptors loss; reconstitution of outer retinal layers; retinal vasculitis.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adalimumab / therapeutic use
  • Administration, Ophthalmic
  • Administration, Oral
  • Adolescent
  • Anti-Inflammatory Agents / therapeutic use
  • Behcet Syndrome / diagnostic imaging
  • Behcet Syndrome / drug therapy*
  • Enzyme Inhibitors / therapeutic use
  • Fluorescein Angiography
  • Glucocorticoids / therapeutic use*
  • Humans
  • Infusions, Intravenous
  • Male
  • Methylprednisolone / therapeutic use
  • Mycophenolic Acid / therapeutic use
  • Ophthalmic Solutions
  • Photoreceptor Cells, Vertebrate / drug effects*
  • Photoreceptor Cells, Vertebrate / pathology
  • Prednisolone / therapeutic use
  • Retinal Pigment Epithelium / diagnostic imaging
  • Retinal Pigment Epithelium / drug effects*
  • Tomography, Optical Coherence
  • Visual Acuity

Substances

  • Anti-Inflammatory Agents
  • Enzyme Inhibitors
  • Glucocorticoids
  • Ophthalmic Solutions
  • Prednisolone
  • Adalimumab
  • Mycophenolic Acid
  • Methylprednisolone