Polycystic ovary syndrome and mitochondrial dysfunction

Reprod Biol Endocrinol. 2019 Aug 16;17(1):67. doi: 10.1186/s12958-019-0509-4.


Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder of premenopausal women worldwide and is characterized by reproductive, endocrine, and metabolic abnormalities. The clinical manifestations of PCOS include oligomenorrhea or amenorrhea, hyperandrogenism, ovarian polycystic changes, and infertility. Women with PCOS are at an increased risk of suffering from type 2 diabetes; me\tabolic syndrome; cardiovascular events, such as hypertension, dyslipidemia; gynecological diseases, including infertility, endometrial dysplasia, endometrial cancer, and ovarian malignant tumors; pregnancy complications, such as premature birth, low birthweight, and eclampsia; and emotional and mental disorders in the future. Although numerous studies have focused on PCOS, the underlying pathophysiological mechanisms of this disease remain unclear. Mitochondria play a key role in energy production, and mitochondrial dysfunction at the cellular level can affect systemic metabolic balance. The recent wide acceptance of functional mitochondrial disorders as a correlated factor of numerous diseases has led to the presupposition that abnormal mitochondrial metabolic markers are associated with PCOS. Studies conducted in the past few years have confirmed that increased oxidative stress is associated with the progression and related complications of PCOS and have proven the relationship between other mitochondrial dysfunctions and PCOS. Thus, this review aims to summarize and discuss previous and recent findings concerning the relationship between mitochondrial dysfunction and PCOS.

Keywords: Abnormal follicular development; And inflammation; Hyperandrogenism; Insulin resistance; Obesity; Oxidative stress; Polycystic ovary syndrome.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / physiopathology
  • Diabetes Mellitus, Type 2 / metabolism
  • Diabetes Mellitus, Type 2 / physiopathology
  • Female
  • Humans
  • Infertility / metabolism
  • Infertility / physiopathology
  • Mitochondria / metabolism
  • Mitochondria / physiology*
  • Ovary / metabolism
  • Ovary / pathology
  • Ovary / physiopathology*
  • Polycystic Ovary Syndrome / diagnosis
  • Polycystic Ovary Syndrome / metabolism
  • Polycystic Ovary Syndrome / physiopathology*
  • Premenopause / metabolism
  • Premenopause / physiology*
  • Risk Factors