Striving Towards the Perfect In Vitro Oral Drug Absorption Model

John P Gleeson; Fiona McCartney

doi:10.1016/j.tips.2019.07.010

Striving Towards the Perfect In Vitro Oral Drug Absorption Model

Trends Pharmacol Sci. 2019 Oct;40(10):720-724. doi: 10.1016/j.tips.2019.07.010. Epub 2019 Aug 16.

Authors

John P Gleeson¹, Fiona McCartney²

Affiliations

¹ Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
² School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: fiona.mccartney@ucd.ie.

PMID: 31422894
DOI: 10.1016/j.tips.2019.07.010

Abstract

Oral drug delivery systems have multiple goals, assessing and enabling intestinal absorption at efficacious doses being one of them. Here we highlight the in vitro advances in modeling drug absorption, which more faithfully reflect human intestinal physiology and reduce the reliance on animal models.

Keywords: Caco-2; drug absorption; intestinal organoids; in vitro-in vivo correlation; oral drug delivery.

MeSH terms

Administration, Oral
Animals
Caco-2 Cells
Humans
In Vitro Techniques
Intestinal Absorption
Intestinal Mucosa / metabolism*
Models, Animal
Organoids / metabolism
Pharmaceutical Preparations / administration & dosage*
Pharmaceutical Preparations / metabolism*
Pharmacokinetics*
Tissue Engineering / methods

Substances

Pharmaceutical Preparations