KEGG Mapper for inferring cellular functions from protein sequences

Protein Sci. 2020 Jan;29(1):28-35. doi: 10.1002/pro.3711. Epub 2019 Aug 29.

Abstract

KEGG is a reference knowledge base for biological interpretation of large-scale molecular datasets, such as genome and metagenome sequences. It accumulates experimental knowledge about high-level functions of the cell and the organism represented in terms of KEGG molecular networks, including KEGG pathway maps, BRITE hierarchies, and KEGG modules. By the process called KEGG mapping, a set of protein coding genes in the genome, for example, can be converted to KEGG molecular networks enabling interpretation of cellular functions and other high-level features. Here we report a new version of KEGG Mapper, a suite of KEGG mapping tools available at the KEGG website (https://www.kegg.jp/ or https://www.genome.jp/kegg/), together with the KOALA family tools for automatic assignment of KO (KEGG Orthology) identifiers used in the mapping.

Keywords: KEGG; KEGG Mapper; KEGG Orthology; KEGG module; genome annotation; pathway analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Computational Biology / methods*
  • Databases, Protein
  • Molecular Sequence Annotation
  • Protein Interaction Mapping
  • Proteins / genetics*
  • Proteins / metabolism*

Substances

  • Proteins