Efficacy and safety of cinnamon in type 2 diabetes mellitus and pre-diabetes patients: A meta-analysis and meta-regression

Serawit Deyno; Kassahun Eneyew; Sisay Seyfe; Naasson Tuyiringire; Emanuel L Peter; Rekik Ashebir Muluye; Casim Umba Tolo; Patrick Engeu Ogwang

doi:10.1016/j.diabres.2019.107815

Efficacy and safety of cinnamon in type 2 diabetes mellitus and pre-diabetes patients: A meta-analysis and meta-regression

Diabetes Res Clin Pract. 2019 Oct:156:107815. doi: 10.1016/j.diabres.2019.107815. Epub 2019 Aug 16.

Authors

Serawit Deyno¹, Kassahun Eneyew², Sisay Seyfe², Naasson Tuyiringire³, Emanuel L Peter⁴, Rekik Ashebir Muluye⁵, Casim Umba Tolo⁶, Patrick Engeu Ogwang⁷

Affiliations

¹ Pharm-BioTechnology and Traditional Medicine Center of Excellence (PHARMBIOTRAC), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda; Faculty of Medicine, College of Medicine and Health Sciences, Hawassa University, P. O. Box 1560, Hawassa, Ethiopia. Electronic address: dserawit@std.must.ac.ug.
² Faculty of Medicine, College of Medicine and Health Sciences, Hawassa University, P. O. Box 1560, Hawassa, Ethiopia.
³ Pharm-BioTechnology and Traditional Medicine Center of Excellence (PHARMBIOTRAC), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda; School of Nursing and Midwifery, College of Medicine and Health Sciences, University of Rwanda, University Avenue, P.O. Box 56, Butare, Rwanda. Electronic address: ntuyiringire@std.must.ac.ug.
⁴ Pharm-BioTechnology and Traditional Medicine Center of Excellence (PHARMBIOTRAC), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda; Department of Innovation, Technology Transfer & Commercialization, National Institute for Medical Research, Barack Obama Drive, P.O. Box 9653, 2448 Dar Es Salaam, Tanzania. Electronic address: epeter@std.must.ac.ug.
⁵ Traditional and Modern Drug Research Directorate, Ethiopian Public Health Institute, Ethiopia.
⁶ Pharm-BioTechnology and Traditional Medicine Center of Excellence (PHARMBIOTRAC), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda. Electronic address: tolocas@must.ac.ug.
⁷ Pharm-BioTechnology and Traditional Medicine Center of Excellence (PHARMBIOTRAC), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda. Electronic address: pogwang@must.ac.ug.

PMID: 31425768
DOI: 10.1016/j.diabres.2019.107815

Abstract

Introduction: Cinnamon has been used as a dietary component and in the management of diabetes mellitus. This study systematically reviewed and synthesized evidence on the efficacy of cinnamon for the treatment of type 2 diabetes mellitus (T2DM) and pre-diabetes patients.

Methods: Databases of Web of Sciences, the Cochrane library, PubMed, CINAHL and SCOPUS were searched. Stata version 13 (College Station, Texas 77845 USA) and RevMan var. 5.3 software were used for meta-analysis. Heterogeneity was assessed using Chi-square and I² tests.

Results: Sixteen randomized controlled studies were included in the meta-analysis. Cinnamon significantly reduced fasting blood glucose (FBG) and homeostatic model assessment for insulin resistance (HOMA-IR) level compared to placebo with weighted mean difference (WMD) of -0.545 (95% CI: -0.910, -0.18) mmol/L, I² = 83.6% and -0.714(-1.388, -0.04), I² = 84.4% respectively. There was no significant change in weighted mean difference of glycosylated hemoglobin A1C (HbA1c) % and lipid profiles (mmol/L). Meta-regression did not show any factor significantly affecting the treatment response.

Conclusion: Cinnamon reduced FBG and HOMA-IR, level in T2DM and pre-diabetes patients compared to placebo. High heterogeneity observed among included studies warrants further clinical trials after standardization of cinnamon formulation.

Keywords: Blood sugar level; Diabetes mellitus; Efficacy; Herbal therapy; Systematic review.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Cinnamomum zeylanicum / chemistry*
Diabetes Mellitus, Type 2 / drug therapy*
Humans
Prediabetic State / drug therapy*