Glidobactins A, B and C, new antitumor antibiotics. I. Production, isolation, chemical properties and biological activity

M Oka; Y Nishiyama; S Ohta; H Kamei; M Konishi; T Miyaki; T Oki; H Kawaguchi

doi:10.7164/antibiotics.41.1331

Glidobactins A, B and C, new antitumor antibiotics. I. Production, isolation, chemical properties and biological activity

J Antibiot (Tokyo). 1988 Oct;41(10):1331-7. doi: 10.7164/antibiotics.41.1331.

Authors

M Oka¹, Y Nishiyama, S Ohta, H Kamei, M Konishi, T Miyaki, T Oki, H Kawaguchi

Affiliation

¹ Bristol-Myers Research Institute, Tokyo Research Center, Japan.

PMID: 3142840
DOI: 10.7164/antibiotics.41.1331

Abstract

New antitumor antibiotic glidobactins A, B and C were isolated from the cultured broth of a gliding bacterium, Polyangium brachysporum sp. nov. No. K481-B101. They are novel molecules carrying the common cyclic tripeptide nucleus substituted with different alpha, beta, gamma, delta-unsaturated fatty acids. Glidobactins exhibit broad inhibitory activity against fungi and yeasts, and prolong the life span of mice inoculated with P388 leukemia cells.

MeSH terms

Animals
Antibiotics, Antineoplastic / isolation & purification*
Antibiotics, Antineoplastic / pharmacology
Chemical Phenomena
Chemistry
Drug Screening Assays, Antitumor
Female
Fungi / drug effects
Leukemia L1210 / drug therapy
Leukemia P388 / drug therapy
Lysine / analogs & derivatives
Lysine / isolation & purification
Lysine / pharmacology
Magnetic Resonance Spectroscopy
Male
Melanoma, Experimental / drug therapy
Mice
Microbial Sensitivity Tests
Myxococcales / metabolism
Peptides, Cyclic
Spectrophotometry, Infrared

Substances

Antibiotics, Antineoplastic
Peptides, Cyclic
glidobactin A
glidobactin B
glidobactin C
Lysine