Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 47 (2), 281-291

Brain 18FDG-PET Pattern in Patients With Alcohol-Related Cognitive Impairment

Affiliations

Brain 18FDG-PET Pattern in Patients With Alcohol-Related Cognitive Impairment

Virgile Clergue-Duval et al. Eur J Nucl Med Mol Imaging.

Abstract

Purpose: Brain positron emission tomography using 18F-fluorodeoxyglucose (18FDG-PET) provides a metabolic assessment of brain function that is useful for differential diagnosis among several neurodegenerative diseases manifested by cognitive impairment (CI). The purpose of the study is to describe the pattern of 18FDG-PET abnormalities in patients with CI related to alcohol use disorder.

Methods: Patients admitted to the addiction medicine department of a university hospital in Paris between January 2017 and October 2018 with a confirmed diagnosis of alcohol-related cognitive impairment (ARCI) or Wernicke encephalopathy (WE) were included. Brain 18FDG-PET uptake was measured after at least 1 month of monitored abstinence from alcohol. Standardized uptake values were obtained for 13 regions of interest (ROI) and normalized to the pons. Individual patients' ROI Z-scores were calculated from healthy sex- and age-matched controls provided by Cortex ID software.

Results: Twenty-five patients were included in the analysis (20 males and 5 females; mean age 57.6 years (45-76 years old)). The group consisted of 19 ARCI and 6 WE cases. The mean hypometabolism was most severe in the prefrontal medial cortex (PFM) (- 2.80 (± 1.30)), the prefrontal lateral cortex (- 2.20 (± 1.35)), and the anterior cingulate cortex (- 2.24 (± 1.19)). Hypometabolism (Z-score < - 2) was most frequent in the PFM (72.0% of the sample, N = 18). Other regions were also affected (with 5.32/13 hypometabolic ROIs on average (SD = 4.16, range 0-13)). The Z-scores in the 13 ROIs did not differ significantly between the ARCI and WE patients (p ≥ 0.05).

Conclusions: Predominant prefrontal and cingulate cortex hypometabolism was the most frequent brain 18FDG-PET pattern in our sample of patients with ARCI and WE.

Keywords: 18F-fluorodeoxyglucose; Alcohol-induced Korsakoff syndrome; Alcohol-related brain damage; Cognitive impairment; Positron emission tomography; Wernicke encephalopathy.

Similar articles

See all similar articles

Cited by 1 article

References

    1. Neuroimage. 2001 Jun;13(6 Pt 1):1164-73 - PubMed

References

    1. Alzheimers Res Ther. 2013 Jan 25;5(1):3 - PubMed

References

    1. Brain. 2007 Jan;130(Pt 1):36-47 - PubMed

References

    1. Intern Med. 2010;49(4):283-7 - PubMed

References

    1. Nat Rev Neurosci. 2011 Oct 20;12(11):652-69 - PubMed

References

    1. Lancet Public Health. 2018 Mar;3(3):e124-e132 - PubMed

References

    1. J Nucl Med. 2017 Aug;58(8):1307-1313 - PubMed

References

    1. Trends Cogn Sci. 2000 Jun;4(6):215-222 - PubMed

References

    1. Neurodegener Dis Manag. 2016 Dec;6(6):509-523 - PubMed

References

    1. Alcohol Clin Exp Res. 1997 Oct;21(7):1278-84 - PubMed

References

    1. Alcohol Alcohol. 2006 Mar-Apr;41(2):151-8 - PubMed

References

    1. Alcohol Alcohol. 2009 Mar-Apr;44(2):148-54 - PubMed

References

    1. Alcohol Clin Exp Res. 2001 Aug;25(8):1206-12 - PubMed

References

    1. Psychiatry Res. 2003 Oct 30;124(2):105-12 - PubMed

References

    1. PET Clin. 2014 Apr;9(2):129-40 - PubMed

References

    1. J Cogn Neurosci. 1997 Mar;9(2):277-93 - PubMed

References

    1. J Neuropsychiatry Clin Neurosci. 1992 Spring;4(2):159-67 - PubMed

References

    1. Alcohol Alcohol. 2009 Mar-Apr;44(2):155-65 - PubMed

References

    1. BMJ. 2018 Aug 1;362:k2927 - PubMed

References

    1. Addiction. 2008 May;103(5):726-35 - PubMed

References

    1. J Nucl Med. 2008 Mar;49(3):390-8 - PubMed

References

    1. Int J Geriatr Psychiatry. 2017 Mar;32(3):256-273 - PubMed

References

    1. Neuron. 2016 May 18;90(4):692-707 - PubMed

References

    1. Biomed Res Int. 2014;2014:503596 - PubMed

References

    1. Alzheimers Dement. 2013 Jan;9(1):63-75.e2 - PubMed

References

    1. J Neuroimaging. 2010 Apr;20(2):204-7 - PubMed

References

    1. J Neurol. 2015 Jun;262(6):1483-92 - PubMed

References

    1. Psychiatry Res. 1994 Dec;54(3):225-39 - PubMed

References

    1. J Nucl Med. 1996 Oct;37(10):1609-13 - PubMed

References

    1. Lancet. 2015 Oct 24;386(10004):1672-82 - PubMed

References

    1. Cortex. 2003 Sep-Dec;39(4-5):1027-45 - PubMed

References

    1. J Comput Assist Tomogr. 1995 Jul-Aug;19(4):541-7 - PubMed

References

    1. Front Hum Neurosci. 2014 Jul 04;8:498 - PubMed

References

    1. J Clin Neurosci. 2012 Feb;19(2):289-98 - PubMed

References

    1. Arch Neurol. 2007 Jun;64(6):830-5 - PubMed

References

    1. J Cereb Blood Flow Metab. 2016 Sep;36(9):1625-40 - PubMed

References

    1. Cochrane Database Syst Rev. 2013 Jul 01;(7):CD004033 - PubMed

References

    1. J Nucl Med. 1998 Nov;39(11):1875-8 - PubMed

References

    1. Lancet. 2017 Dec 16;390(10113):2673-2734 - PubMed

References

    1. Ann Neurol. 1990 Dec;28(6):775-85 - PubMed

References

    1. J Cereb Blood Flow Metab. 1987 Aug;7(4):415-20 - PubMed

References

    1. Alcohol Alcohol. 2009 Mar-Apr;44(2):136-40 - PubMed

References

    1. PLoS One. 2009 Nov 13;4(11):e7748 - PubMed

References

    1. Alzheimers Dement (Amst). 2018 Aug 29;10:583-594 - PubMed

References

    1. J Nucl Med. 2005 Feb;46(2):233-9 - PubMed

References

    1. World J Biol Psychiatry. 2018 Jun;19(4):244-328 - PubMed

References

    1. Eur J Nucl Med Mol Imaging. 2018 Jul;45(9):1497-1508 - PubMed

LinkOut - more resources

Feedback