Abnormalities of diaphragmatic muscle in neonates with ventilated lungs

J Pediatr. 1988 Dec;113(6):1074-7. doi: 10.1016/s0022-3476(88)80585-7.


Several infants and neonates who had received long-term ventilatory assistance had subnormal diaphragmatic muscle mass on gross necropsy examination. We conducted a retrospective study of our hospital infant necropsy files to determine whether prolonged ventilatory support was associated with diminution in myofiber cross-sectional area selectively affecting the diaphragm. We found that long-term ventilatory assistance may predispose diaphragmatic myofibers to disuse atrophy or to failure or normal growth. This phenomenon may contribute to difficulties in weaning infants from ventilatory support.

MeSH terms

  • Diaphragm / pathology*
  • Humans
  • Infant
  • Infant, Newborn
  • Long-Term Care
  • Muscular Atrophy / pathology
  • Respiration, Artificial*
  • Respiratory Distress Syndrome, Newborn / pathology*
  • Retrospective Studies