Bursting the Notch Bubble: New Insights into In Vivo Transcriptional Dynamics

Dev Cell. 2019 Aug 19;50(4):393-394. doi: 10.1016/j.devcel.2019.07.028.


In this issue of Developmental Cell,Lee et al. (2019) and Falo-Sanjuan et al. (2019) examine the transcriptional dynamics of Notch signaling in vivo. Both groups show that Notch signaling produces "bursty" transcriptional responses and that variance in these responses stems from changes in duration, not frequency, of transcriptional bursts.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Signal Transduction*