Bursting the Notch Bubble: New Insights into In Vivo Transcriptional Dynamics

Caroline Vissers; Ryoichiro Kageyama

doi:10.1016/j.devcel.2019.07.028

Bursting the Notch Bubble: New Insights into In Vivo Transcriptional Dynamics

Dev Cell. 2019 Aug 19;50(4):393-394. doi: 10.1016/j.devcel.2019.07.028.

Authors

Caroline Vissers¹, Ryoichiro Kageyama²

Affiliations

¹ The Graduate Program of Biochemistry, Cellular, and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
² Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto 606-8501, Japan. Electronic address: kageyama.ryoichiro.8r@kyoto-u.ac.jp.

PMID: 31430449
DOI: 10.1016/j.devcel.2019.07.028

Abstract

In this issue of Developmental Cell,Lee et al. (2019) and Falo-Sanjuan et al. (2019) examine the transcriptional dynamics of Notch signaling in vivo. Both groups show that Notch signaling produces "bursty" transcriptional responses and that variance in these responses stems from changes in duration, not frequency, of transcriptional bursts.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Signal Transduction*

Grants and funding

T32 GM007445/GM/NIGMS NIH HHS/United States