Mycobacterium bovis sigF mutant exhibits altered surface phenotype and compromised pathogenesis

Debashis Dutta; Vishal Srivastava; Ashutosh Tripathi; Vandana Singh; Mohd Mustkim Ansari; Garima Pant; Manisha Mishra; Sharad Sharma; Jagadehswar Reddy Thota; Pradhyumna Kumar Singh; Bhupendra N Singh

doi:10.1016/j.tube.2019.07.006

Mycobacterium bovis sigF mutant exhibits altered surface phenotype and compromised pathogenesis

Tuberculosis (Edinb). 2019 Sep:118:101855. doi: 10.1016/j.tube.2019.07.006. Epub 2019 Jul 31.

Authors

Affiliations

¹ Department of Immunology and Microbiology, The Scripps Research Institute, 130 Scripps Way, 3C1, FL33458, USA; Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, 226031, India. Electronic address: ddutta@scripps.edu.
² Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, 226031, India. Electronic address: genius.vishu@gmail.com.
³ Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, 226031, India. Electronic address: 1ashutripathi@gmail.com.
⁴ Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, 226031, India. Electronic address: singh.vandana02@gmail.com.
⁵ Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, 226031, India. Electronic address: mustkim.bhu@gmail.com.
⁶ Electron Microscopy Unit, CSIR-Central Drug Research Institute, Lucknow, 226031, India. Electronic address: garimajune2@gmail.com.
⁷ CSIR-National Botanical Research Institute, Lucknow, 226001, India. Electronic address: manisha.nbri@gmail.com.
⁸ Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, 226031, India. Electronic address: sharadmandira@yahoo.com.
⁹ Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Lucknow, 226031, India. Electronic address: tjreddy@cdri.res.in.
¹⁰ CSIR-National Botanical Research Institute, Lucknow, 226001, India. Electronic address: pksingh@nbri.res.in.
¹¹ Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, 226031, India. Electronic address: bnsingh@cdri.res.in.

PMID: 31430695
DOI: 10.1016/j.tube.2019.07.006

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bacterial Proteins / genetics*
Bacterial Proteins / physiology
Biofilms
Cell Membrane Permeability / genetics
Cell Membrane Permeability / physiology
DNA, Bacterial / genetics
Lipid Metabolism / physiology
Mice, Inbred BALB C
Microscopy, Electron, Scanning
Mutation*
Mycobacterium bovis / genetics
Mycobacterium bovis / growth & development
Mycobacterium bovis / pathogenicity*
Mycobacterium bovis / ultrastructure
Phenotype
Proteome / analysis
Sigma Factor / genetics*
Sigma Factor / physiology
Tuberculosis / microbiology
Virulence / genetics

Substances

Bacterial Proteins
DNA, Bacterial
FliA protein, Bacteria
Proteome
Sigma Factor