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Rationale and Design of a Pilot Study to Evaluate the Acceptability and Effectiveness of a Revised Protein Sparing Modified Fast (rPSMF) for Severe Obesity in a Pediatric Tertiary Care Weight Management Clinic

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Rationale and Design of a Pilot Study to Evaluate the Acceptability and Effectiveness of a Revised Protein Sparing Modified Fast (rPSMF) for Severe Obesity in a Pediatric Tertiary Care Weight Management Clinic

I U Eneli et al. Contemp Clin Trials Commun.

Abstract

Aggressive dietary interventions may provide an accessible treatment option for children and adolescents with severe obesity who are not successful with traditional lifestyle behavioral interventions or do not want or qualify for weight loss surgery. One such intensive dietary option is the protein sparing modified fast (PSMF). The PSMF involves minimal carbohydrate intake to induce ketosis, while maintaining adequate or high protein intake to minimize catabolism. The PSMF, under medical supervision, can be an effective and safe intervention for children and adolescents, yet the PSMF diet is not regularly used in the treatment of pediatric severe obesity. This paper describes the rationale and design for a pilot study to evaluate the acceptability and effectiveness of a revised PSMF (rPSMF) implemented as a weight loss treatment option for children and adolescents with severe obesity in a pediatric tertiary care weight management clinic. The primary aim of the study is to evaluate the acceptability of the rPSMF as assessed by adherence, satisfaction with the intervention, and participation rate using quantitative and qualitative methods. The secondary aim is to investigate the effectiveness of the rPSMF on improving a) anthropometric measures (weight, body mass index [BMI], BMI z-score); b) metabolic measures (lipid profile, glycosylated hemoglobin, liver function tests); and c) quality of life. Results of this study will provide guidance for the standardization of a pediatric rPSMF protocol in a clinic setting, delineate which factors improve or hinder adherence and weight loss and provide preliminary data for a multicenter randomized controlled trial.

Clinicaltrialsgov identifier: NCT03899311.

Keywords: Children and adolescents; Protein sparing modified fast; Severe obesity; Weight management.

Figures

Fig. 1
Fig. 1
Schematic representation of the rPSMF intervention and study protocol. *: rPSMF intervention will be implemented per the clinic protocol. **: The study is designed to investigate components of the rPSMF protocol, implementation and outcomes.

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References

    1. Skinner A.C., Ravanbakht S.N., Skelton J.A. Prevalence of obesity and severe obesity in US children, 1999–2016. Pediatrics. 2018 - PubMed
    1. Bass R., Eneli I. Severe childhood obesity: an under-recognised and growing health problem. Postgrad. Med. 2015;91(1081):639–645. - PubMed
    1. Kelly A.S., Barlow S.E., Rao G. Severe obesity in children and adolescents: identification, associated health risks, and treatment approaches a scientific statement from the American heart association. Circulation. 2013;128(15):1689–1712. - PubMed
    1. Ward Z.J., Long M.W., Resch S.C. Simulation of growth trajectories of childhood obesity into adulthood. N. Engl. J. Med. 2017;377(22):2145–2153. - PubMed
    1. Benestad B., Lekhal S., Smastuen M.C. Camp-based family treatment of childhood obesity: randomised controlled trial. Arch. Dis. Child. 2017;102(4):303–310. - PMC - PubMed

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