Limonoid 7-Deacetoxy-7-oxogedunin from Andiroba, Carapa guianensis, Meliaceae, Decreased Body Weight Gain, Improved Insulin Sensitivity, and Activated Brown Adipose Tissue in High-Fat-Diet-Fed Mice

J Agric Food Chem. 2019 Sep 11;67(36):10107-10115. doi: 10.1021/acs.jafc.9b04362. Epub 2019 Sep 3.


We examined the antiobesity effect of a limonoid 7-deacetoxy-7-oxogedunin, named CG-1, purified from the seeds of Carapa guianensis, Meliaceae, known as andiroba in high-fat-diet (HFD)-fed mice. C57BL/6 mice were fed a low-fat diet or an HFD and orally administered CG-1 (20 mg/kg) for 7 weeks. CG-1 lowered the body weight gain and improved the serum triglyceride level and insulin sensitivity in HFD-fed mice. The expression level of the adipogenesis-related genes was lowered by CG-1 in the visceral white adipose tissue (vWAT). The mRNA expression level of the macrophage-related genes decreased in vWAT following the administration of CG-1 to HFD-fed mice. It is noteworthy that CG-1 activated the brown adipose tissue (BAT) with enhanced expression of uncoupling protein 1 and increased the rectal temperature in HFD-fed mice. These results indicate that the limonoid CG-1 decreased body weight gain and ameliorated hypertriglyceridemia and insulin resistance with the activation of BAT in HFD-fed mice.

Keywords: BAT; andiroba; insulin resistance; limonoid; obesity.

MeSH terms

  • Adipose Tissue, Brown / drug effects*
  • Adipose Tissue, Brown / metabolism
  • Animals
  • Anti-Obesity Agents / administration & dosage*
  • Diet, High-Fat / adverse effects
  • Humans
  • Insulin Resistance*
  • Limonins / administration & dosage*
  • Male
  • Meliaceae / chemistry*
  • Mice
  • Mice, Inbred C57BL
  • Obesity / drug therapy*
  • Obesity / genetics
  • Obesity / metabolism
  • Obesity / physiopathology
  • Plant Extracts / administration & dosage*
  • Seeds / chemistry
  • Triglycerides / blood
  • Uncoupling Protein 1 / genetics
  • Uncoupling Protein 1 / metabolism
  • Weight Gain / drug effects


  • Anti-Obesity Agents
  • Limonins
  • Plant Extracts
  • Triglycerides
  • Uncoupling Protein 1