Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients

Epilepsy Res. 1987 May;1(3):209-12. doi: 10.1016/0920-1211(87)90043-x.


The effect of the combined administration of gamma-aminobutyric acid (GABA) and phosphatidylserine was evaluated in a pilot study of 42 patients with drug-resistant epilepsy. The group included patients with complex partial seizures, simple partial seizures and absence seizures. Patients with complex partial seizures and simple partial seizures showed no significant improvement; on the other hand, there was a remarkable decrease in absence seizures, linearly related to the dose of GABA and phosphatidylserine. Side effects occurred in 9 patients and were usually mild.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anticonvulsants / therapeutic use
  • Epilepsy / drug therapy*
  • Epilepsy / metabolism
  • Epilepsy, Absence / drug therapy*
  • Epilepsy, Absence / metabolism
  • Female
  • Humans
  • Male
  • Middle Aged
  • Phosphatidylserines / adverse effects
  • Phosphatidylserines / therapeutic use*
  • gamma-Aminobutyric Acid / adverse effects
  • gamma-Aminobutyric Acid / therapeutic use*


  • Anticonvulsants
  • Phosphatidylserines
  • gamma-Aminobutyric Acid