Microbe Profile: Thermococcus kodakarensis: the model hyperthermophilic archaeon

Microbiology (Reading). 2019 Nov;165(11):1166-1168. doi: 10.1099/mic.0.000839.

Abstract

Thermococcus kodakarensis is a hyperthermophilic Euryarchaeon that grows well under laboratory conditions and, being naturally competent for genetic transformation, it has become a widely studied experimental model species. With the genome sequence available since 2004, combining genetic, enzymological and structural biochemical approaches has revealed previously unknown and unanticipated features of archaeal molecular biology and metabolism. T. kodakarensis DNA polymerase is already commercialized and with the details of metabolism and hydrogenase available, generating H2 from biopolymers solubilized at high temperatures, most notably chitin, now seems a very attractive possibility as a renewable energy bioprocess.

Keywords: Thermococcus kodakarensis; archaea; genetics; hyperthermophile.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Archaeal Proteins / genetics
  • Archaeal Proteins / metabolism
  • Genome, Bacterial
  • Hydrogen / metabolism
  • Phylogeny
  • Thermococcus / classification*
  • Thermococcus / physiology*
  • Thermotolerance

Substances

  • Archaeal Proteins
  • Hydrogen