Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Aug 22;19(1):735.
doi: 10.1186/s12879-019-4365-9.

Clinical Profiles of Early and Tuberculosis-Related Mortality in South Korea Between 2015 and 2017: A Cross-Sectional Study

Affiliations
Free PMC article

Clinical Profiles of Early and Tuberculosis-Related Mortality in South Korea Between 2015 and 2017: A Cross-Sectional Study

Jinsoo Min et al. BMC Infect Dis. .
Free PMC article

Abstract

Background: Although the incidence of tuberculosis (TB) has decreased in South Korea, the mortality rate remains high. TB mortality is a key indicator for TB control interventions. The purpose of this study was to assess early and TB-related mortality during anti-TB treatment and describe the associated clinical characteristics.

Methods: A multicenter cross-sectional study was performed across South Korea. Patients with pulmonary TB who died during anti-TB treatment and whose records were submitted to the national TB surveillance system between 2015 and 2017 were enrolled. All TB deaths were categorized based on cause (TB-related or non-TB-related) and timing (early or late). We identified statistical associations using the frequency table, chi-square test, and binary logistic regression.

Results: Of 5595 notifiable mortality cases, 3735 patients with pulmonary TB were included in the analysis. There were 2541 (68.0%) male patients, and 2935 (78.6%) mortality cases were observed in patients older than 65 years. There were 944 (25.3%) cases of TB-related death and 2545 (68.1%) cases of early death. Of all cases, 187 (5.0%) patients were diagnosed post-mortem and 38 (1.0%) patients died on the first day of treatment. Low body mass index (adjusted odds ratio (aOR) = 1.26; 95% confidence interval (CI) = 1.08-1.48), no reported illness (aOR = 1.36; 95% CI = 1.10-1.68), bilateral disease on chest X-ray (aOR = 1.30; 95% CI = 1.11-1.52), and positive acid-fast bacilli smear result (aOR = 1.30; 95% CI = 1.11-1.52) were significantly associated with early death, as well as TB-related death. Acute respiratory failure was the most common mode of non-TB-related death. Malignancy was associated with both late (aOR = 0.71; 95% CI = 0.59-0.89) and non-TB-related (aOR = 0.35; 95% CI = 0.26-0.46) death.

Conclusions: A high proportion of TB death was observed in elderly patients and attributed to non-TB-related causes. Many TB-related deaths occurred during the intensive phase, particularly within the first month. Further studies identifying risk factors for different causes of TB death at different phases of anti-TB treatment are warranted for early targeted intervention in order to reduce TB mortality.

Keywords: Death; Elderly; Korea; PPM; Private-public mix.

Conflict of interest statement

All authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of enrollment of tuberculosis mortality cases between 2015 and 2017, which were finally categorized based on cause (tuberculosis-related and non-tuberculosis related) and timing (early and late) TB, tuberculosis
Fig. 2
Fig. 2
Number of tuberculosis-related, non-tuberculosis-related, and all death cases stratified by intervals between diagnosis and death. TB, tuberculosis
Fig. 3
Fig. 3
Log-Log plot describing variables, which were significantly associated with subsets of TB death (TB-related, non-TB-related, early and late deaths). TB, tuberculosis; AFB, acid-fast bacillus; BMI, body mass index; Hx, history

Similar articles

See all similar articles

Cited by 1 article

References

    1. World Health Organization. Global Tuberculosis Report. Geneva: WHO; 2018. https://www.who.int/tb/publications/global_report/en/. Accessed 18 June 2019.
    1. World Health Organization. Implementing the end TB strategy: the essentials. Geneva: WHO; 2015. https://www.who.int/tb/publications/2015/The_Essentials_to_End_TB/en/. Accessed 18 June 2019.
    1. Go U, Park M, Kim U-N, Lee S, Han S, Lee J, Yang J, Kim J, Park S, Kim Y, et al. Tuberculosis prevention and care in Korea: evolution of policy and practice. J Clin Tuberc Other Mycobact Dis. 2018;11:28–36. doi: 10.1016/j.jctube.2018.04.006. - DOI
    1. Korea Centers for Disease Control & Prevention. Annual Report on the Notified Tuberculosis in Korea. Osong: KCDC; 2016. http://www.cdc.go.kr/CDC/cms/content/mobile/78/73878_view.html. Accessed 20 Aug 2019.
    1. Min J, Mi Shin Y, Lee WJ, Truong TT, Kang ES, An JY, Choe KH, Man Lee K. Clinical features of octogenarian patients with tuberculosis at a tertiary hospital in South Korea. J Int Med Res. 2018;47:271–280. doi: 10.1177/0300060518800597. - DOI - PMC - PubMed
Feedback