Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells

Nature. 1988 Dec 15;336(6200):690-2. doi: 10.1038/336690a0.


Leukaemia inhibitory factor (LIF) is a cytokine that induces macrophage differentiation of the murine M1 myeloid leukaemia cell line. We have isolated a cDNA clone encoding a novel human haemopoietic growth factor, human interleukin for DA cells (HILDA) that supports the proliferation of the murine interleukin-3-dependent leukaemic cell line, DA-la (refs 3-5). HILDA proved to be identical to LIF. The demonstration that the differentiation factor LIF will also serve as a growth factor for at least one myeloid leukaemic cell line provides further evidence that the distinction between growth-promoting and differentiation-inducing activities are largely determined by the target cell type.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Base Sequence
  • Cell Differentiation / drug effects
  • Cell Line
  • Growth Inhibitors / analysis*
  • Humans
  • Interleukin-6*
  • Interleukins / analysis*
  • Leukemia Inhibitory Factor
  • Lymphokines*
  • Molecular Sequence Data
  • Molecular Weight
  • Nucleic Acid Hybridization
  • Rats
  • Recombinant Proteins / analysis


  • Growth Inhibitors
  • Interleukin-6
  • Interleukins
  • LIF protein, human
  • Leukemia Inhibitory Factor
  • Lymphokines
  • Recombinant Proteins