The hunt for RNA polymerase II elongation factors: a historical perspective

Nat Struct Mol Biol. 2019 Sep;26(9):771-776. doi: 10.1038/s41594-019-0283-1. Epub 2019 Aug 22.


The discovery of the three eukaryotic nuclear RNA polymerases paved the way for serious biochemical investigations of eukaryotic transcription and the identification of eukaryotic transcription factors. Here we describe this adventure from our vantage point, with a focus on the hunt for factors that regulate elongation by RNA polymerase II.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Biochemistry / history*
  • Eukaryota / enzymology*
  • History, 20th Century
  • History, 21st Century
  • Molecular Biology / history*
  • RNA Polymerase II / metabolism*
  • Transcription, Genetic*
  • Transcriptional Elongation Factors / isolation & purification*
  • Transcriptional Elongation Factors / metabolism*


  • Transcriptional Elongation Factors
  • RNA Polymerase II