Persistent type IV hypersensitivity after cyanoacrylate closure of the great saphenous vein

Andrew D Jones; Edward M Boyle; Randy Woltjer; Jason P Jundt; Adam N Williams

doi:10.1016/j.jvscit.2019.05.004

Persistent type IV hypersensitivity after cyanoacrylate closure of the great saphenous vein

J Vasc Surg Cases Innov Tech. 2019 Aug 7;5(3):372-374. doi: 10.1016/j.jvscit.2019.05.004. eCollection 2019 Sep.

Authors

Andrew D Jones¹, Edward M Boyle¹, Randy Woltjer², Jason P Jundt³, Adam N Williams⁴

Affiliations

¹ Inovia Vein Specialty Centers, Bend, Ore.
² Department of Pathology, Oregon Health Sciences University, Portland, Ore.
³ Oregon Vascular Specialist, Bend, Ore.
⁴ Summit Medical Group, Bend, Ore.

Abstract

The VenaSeal (Medtronic, Minneapolis, Minn) cyanoacrylate closure system is a nonthermal technique for ablating saphenous veins using a proprietary n-butyl cyanoacrylate. One possible side effect is an allergic reaction to cyanoacrylate. We report the case of a 49-year-old woman treated with cyanoacrylate closure who developed a persistent type IV hypersensitivity reaction. The patient elected to have the vein excised, and the histologic features were consistent with a type IV hypersensitivity reaction.

Keywords: Allergic reaction; Endovenous ablation; Hypersensitivity; Varicose vein; VenaSeal.

Publication types

Case Reports