Toward understanding the origin and evolution of cellular organisms

Protein Sci. 2019 Nov;28(11):1947-1951. doi: 10.1002/pro.3715. Epub 2019 Sep 9.


In this era of high-throughput biology, bioinformatics has become a major discipline for making sense out of large-scale datasets. Bioinformatics is usually considered as a practical field developing databases and software tools for supporting other fields, rather than a fundamental scientific discipline for uncovering principles of biology. The KEGG resource that we have been developing is a reference knowledge base for biological interpretation of genome sequences and other high-throughput data. It is now one of the most utilized biological databases because of its practical values. For me personally, KEGG is a step toward understanding the origin and evolution of cellular organisms.

Keywords: KEGG; KEGG MEDICUS; KEGG module; pathway mapping; reaction module.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Computational Biology*
  • Databases, Genetic*
  • High-Throughput Screening Assays*
  • Humans
  • Software