Active Surveillance Versus Immediate Surgery: Questionnaire Survey on the Current Treatment Strategy for Adult Patients with Low-Risk Papillary Thyroid Microcarcinoma in Japan

Thyroid. 2019 Nov;29(11):1563-1571. doi: 10.1089/thy.2019.0211. Epub 2019 Sep 25.

Abstract

Background: Two Japanese prospective trials of active surveillance (AS) for adult patients with low-risk papillary thyroid carcinoma (PTC) ≤1 cm (cT1aN0M0 PTMC) have verified the safety of AS in oncological control and its superiority over immediate surgery with respect to unfavorable outcomes. Thus, AS has been accepted as an alternative to immediate surgery for asymptomatic papillary thyroid microcarcinomas (PTMCs). However, the real-world clinical approach for PTMC is unknown. Thus, this study aimed to investigate the current state of management of asymptomatic PTMCs in Japan. Methods: We conducted a questionnaire survey on the actual treatment patterns for adult patients with low-risk PTMCs. The subjects were member institutions of the Japan Association of Endocrine Surgery (JAES) or Japanese Society of Thyroid Surgery (JSTS), including the departments of surgery and head and neck surgery (HNS). Results: Responses were obtained from 134 institutes, where 72.4% of Japanese thyroid cancer cases operated by surgeons were treated. For suspicious tumors on ultrasound, 18 responders (13.4%) conducted cytological examination routinely, while 69 (51.5%) and 40 (27.8%) conducted it only for tumors >5 and >10 mm, respectively. After the diagnosis, 42 responders (31.3%) recommend AS, 35 (26.1%) recommend immediate surgery as the management, and 52 (38.8%) allowed patients to decide the treatment course. The present responders tended to recommend surgery for PTMCs that were located adjacent to the dorsal surface of the thyroid, were multiple, or measured almost 10 mm in size. At these institutions, 1176 patients with PTMC underwent surgery in 2017, accounting for 18.1% of surgeries for PTC. During the succeeding three months, 310 of 576 (53.8%) PTMC patients underwent AS. The treatment strategies did not differ between the departments (Surgery or HNS). The institutions that have six or more surgeons, that were located in metropolitan areas, or that were certified by JAES or JSTS performed AS more actively. Conclusion: More than 50% of low-risk PTMCs are on AS in Japan. However, the indication and recommendation for AS vary significantly between institutions. To improve the implementation of this management modality, physicians and patients should be further educated, and the sociomedical environment should be improved.

Keywords: active surveillance; immediate surgery; management; papillary thyroid microcarcinoma; questionnaire survey.

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Papillary / diagnostic imaging
  • Carcinoma, Papillary / surgery*
  • Carcinoma, Papillary / therapy*
  • Disease Management
  • Female
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk
  • Surgeons
  • Surveys and Questionnaires
  • Thyroid Neoplasms / diagnostic imaging
  • Thyroid Neoplasms / surgery*
  • Thyroid Neoplasms / therapy*
  • Thyroidectomy
  • Time-to-Treatment
  • Treatment Outcome
  • Ultrasonography
  • Watchful Waiting*

Supplementary concepts

  • Papillary Thyroid Microcarcinoma