Weekly cuirass ventilation improves blood gases and inspiratory muscle strength in patients with chronic air-flow limitation and hypercarbia

Am Rev Respir Dis. 1988 Sep;138(3):617-23. doi: 10.1164/ajrccm/138.3.617.


We studied the effects of an 8-h, once-a-week schedule of cuirass ventilation (CV) in 5 patients with advanced chronic air-flow limitation and chronic hypercarbia (PaCO2, 58.6 +/- 10.1 mm Hg; mean +/- SD). Repeated measurements of arterial blood gases, maximal inspiratory mouth pressure (P1max), 12-min walking distance, and respiratory cycle were performed during a 1-month run-in period. Quality of life and transdiaphragmatic pressure were measured once. All patients completed the planned 4-month study. Four of them were ventilated for longer periods because CV could not be discontinued at the end of the study. PaCO2 showed a significant fall starting during the first month; PaO2 significantly increased from the second month, whereas P1max significantly rose from the third month on. Maximal transdiaphragmatic pressure increased in the 2 patients with abnormal baseline values. The fall in PaCO2 was associated with an increase in tidal volume because of a longer inspiratory time. Significant improvements in quality of life and in the 12-min walking distance were observed. We conclude that weekly CV improves blood gases, inspiratory muscle strength, and clinical conditions of patients with chronic air-flow limitation and chronic hypercarbia, probably because of correction of chronic inspiratory muscle fatigue.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Gas Analysis
  • Carbon Dioxide / blood*
  • Evaluation Studies as Topic
  • Humans
  • Hypercapnia / blood
  • Hypercapnia / physiopathology
  • Hypercapnia / therapy*
  • Lung Diseases, Obstructive / blood
  • Lung Diseases, Obstructive / physiopathology
  • Lung Diseases, Obstructive / therapy*
  • Oxygen / blood*
  • Respiration, Artificial / methods*
  • Respiratory Function Tests
  • Respiratory Muscles / physiopathology*
  • Time Factors


  • Carbon Dioxide
  • Oxygen