When Fasting Gets Tough, the Tough Immune Cells Get Going-or Die

Cell. 2019 Aug 22;178(5):1038-1040. doi: 10.1016/j.cell.2019.07.052.


Cycles of fasting reduce autoimmunity and activate lymphocyte-dependent killing of cancer cells, but the mechanisms remain poorly understood. Three studies in this issue of Cell begin to reveal the drastic and complex effects of fasting and severe calorie restriction on the levels and localization of different immune cells and the mechanisms responsible for them.

Publication types

  • Comment

MeSH terms

  • Fasting*
  • Immunity, Mucosal*