Role of Peptide Hormones in the Adaptation to Altered Dietary Protein Intake

Nutrients. 2019 Aug 23;11(9):1990. doi: 10.3390/nu11091990.


Dietary protein profoundly influences organismal traits ultimately affecting healthspan. While intracellular signalling downstream of altered amino acid supply is undoubtedly important, peptide hormones have emerged as critical factors determining systemic responses to variations in protein intake. Here the regulation and role of certain peptides hormones in such responses to altered dietary protein intake is reviewed.

Keywords: FGF21; PYY; amino acid; endocrine; glucagon; insulin.

Publication types

  • Review

MeSH terms

  • Animals
  • Appetite Regulation
  • Diet, High-Protein*
  • Diet, Protein-Restricted*
  • Dietary Proteins / administration & dosage*
  • Dietary Proteins / metabolism
  • Energy Metabolism*
  • Feeding Behavior
  • Humans
  • Peptide Hormones / metabolism*
  • Signal Transduction


  • Dietary Proteins
  • Peptide Hormones