Autoantibodies in immune-mediated inflammatory neuropathies

Med Clin (Barc). 2019 Nov 15;153(9):360-367. doi: 10.1016/j.medcli.2019.06.007. Epub 2019 Aug 20.
[Article in English, Spanish]


Inflammatory neuropathies are a rare and heterogeneous group of diseases of the nervous system characterized by the dysfunction and damage of different structures of the peripheral nerves. This group includes Guillain-Barré syndrome, chronic demyelinating inflammatory polyradiculoneuropathy, multifocal motor neuropathy or neuropathies associated with monoclonal gammopathy. The aetiology of these diseases is unknown, but B cells and autoantibodies play a key role in their pathogenesis. Autoantibodies against peripheral nerve molecules such as gangliosides, proteins of the Ranvier node or myelin-associated glycoprotein have been described, allowing the identification of subgroups of patients with specific clinical phenotypes. For all these reasons, these antibodies are useful in clinical practice. This review focuses on the diagnostic and therapeutic relevance of autoantibodies in inflammatory neuropathies.

Keywords: Autoantibodies; Autoanticuerpos; CIDP; GMSI-P; Guillain-Barré syndrome; Immune-mediated neuropathies; MGUS-P; Multifocal motor neuropathy; Neuropatía motora multifocal; Neuropatías inmunomediadas; Síndrome de Guillain-Barré.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoantibodies / immunology*
  • Guillain-Barre Syndrome / immunology
  • Humans
  • Inflammation / immunology*
  • Monoclonal Gammopathy of Undetermined Significance / immunology
  • Peripheral Nervous System Diseases / immunology*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / immunology


  • Autoantibodies