A nanocomposite prepared from reduced graphene oxide, gold nanoparticles and poly(2-amino-5-mercapto-1,3,4-thiadiazole) for use in an electrochemical sensor for doxorubicin

Mikrochim Acta. 2019 Aug 23;186(9):641. doi: 10.1007/s00604-019-3761-6.


A nanocomposite was prepared with reduced graphene oxide, gold nanoparticles and an electropolymerized film made from 2-amino-5-mercapto-1,3,4-thiadiazole. An electrochemical sensor for doxorubicin (DOX) was constructed by modifying a glassy carbon electrode (GCE) with the nanocomposite. The modified GCE was studied by electrochemical techniques which showed it to enable highly sensitive sensing of DOX. Response (typically measured at a typical working potential of -0.56 V vs. Ag/AgCl) is linear in the 30 pM to 30 nM and 30 nM to 30 μM DOX concentration ranges, with a limit of detection (LOD) of 9 pM (at an S/N ratio of 3). The method was applied to the determination of DOX in serum and gave recoveries that ranged between 92 and 108%. Graphical abstract A combination of materials consisting of reduced graphene oxide (rGO), gold nanoparticles (AuNPs) and an electropolymerized film of 2-amino-5-mercapto-1,3,4-thiadiazole (poly-AMT, PAMT) is described. The nanocomposite was placed on a glassy carbon elkectrode (GCE) in order to fabricate an electrochemical sensor for doxorubicin (DOX).

Keywords: Doxorubicin; Electrochemical sensor; Gold nanoparticles; Poly 2-amino-5-mercapto-1,3,4-thiadiazole; Reduced graphene oxide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antineoplastic / analysis*
  • Biosensing Techniques*
  • Doxorubicin / analysis*
  • Electrochemical Techniques*
  • Gold / chemistry
  • Graphite / chemistry
  • Metal Nanoparticles / chemistry
  • Molecular Conformation
  • Nanocomposites / chemistry*
  • Oxidation-Reduction
  • Particle Size
  • Polymers / chemistry
  • Surface Properties
  • Thiadiazoles / chemistry


  • Antibiotics, Antineoplastic
  • Polymers
  • Thiadiazoles
  • graphene oxide
  • Gold
  • Graphite
  • Doxorubicin
  • 2-amino-5-mercapto-1,3,4-thiadiazole