Neonatal Neospora caninum infection in dogs: isolation of the causative agent and experimental transmission

J Am Vet Med Assoc. 1988 Nov 15;193(10):1259-63.


Neospora caninum infection was diagnosed in 5 young dogs from 2 litters with a common parentage. The pups were born healthy, but developed hind limb paresis 5 to 8 weeks after birth. The predominant lesions were polyradiculoneuritis and granulomatous polymyositis. Neospora caninum was seen microscopically in sections of naturally infected pups, and was isolated in cell cultures, mice, and dogs inoculated with infected canine tissues. Antibodies to N caninum were detected in sera of infected dogs by indirect fluorescent antibody test.

MeSH terms

  • Animals
  • Animals, Newborn / parasitology*
  • Apicomplexa / isolation & purification
  • Dog Diseases / parasitology*
  • Dog Diseases / pathology
  • Dog Diseases / transmission
  • Dogs
  • Female
  • Male
  • Protozoan Infections / pathology
  • Protozoan Infections / transmission
  • Protozoan Infections, Animal*