Targeted juglone blocks the invasion and metastasis of HPV-positive cervical cancer cells

J Pharmacol Sci. 2019 Jul;140(3):211-217. doi: 10.1016/j.jphs.2019.06.013. Epub 2019 Aug 10.


Human papillomaviruses (HPVs), for instance, HPV 16 and HPV 18, are concerned associated with cervical cancer. Thus, it is essential to suppress HPVs-in HPV-positive cervical cancer for treating cervical cancer. The purpose of this study was to explore the proposed molecular mechanisms, which that underlies the antintumor potential of juglone to treat of HPV-positive on cervical cancer cells. The results showed that juglone suppressed HPV-positive cell growth in a dose- and time-dependent way. In addition, cell invasion and metastasis were also inhibited by juglone. Nevertheless, when pin 1 was knocked down in HPV-positive cells, cell proliferation, invasion and metastasis were reduced. This study was designed to acquire an understanding of the mechanism of invasion and metastasis in HPV-positive cells suppressed by juglone. It provides evidence of the advantageous use of juglone in the future.

Keywords: Cervical cancer cells; HPV-positive; Invasion; Juglone; Metastasis.

MeSH terms

  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Female
  • HeLa Cells
  • Humans
  • Naphthoquinones / pharmacology*
  • Neoplasm Invasiveness / pathology*
  • Neoplasm Metastasis / drug therapy*
  • Papillomaviridae / pathogenicity
  • Papillomavirus Infections / complications*
  • Papillomavirus Infections / virology
  • Uterine Cervical Neoplasms / drug therapy*
  • Uterine Cervical Neoplasms / etiology
  • Uterine Cervical Neoplasms / virology*


  • Naphthoquinones
  • juglone