Comparison of QT interval variability of coronary patients without myocardial infarction with that of patients with old myocardial infarction

Lianke Yao; Peng Li; Changchun Liu; Yunxiu Hou; Chang Yan; Liping Li; Ke Li; Xinpei Wang; Aruna Deogire; Chunlei Du; Huan Zhang; Jikuo Wang; Han Li

doi:10.1016/j.compbiomed.2019.103396

Comparison of QT interval variability of coronary patients without myocardial infarction with that of patients with old myocardial infarction

Comput Biol Med. 2019 Oct:113:103396. doi: 10.1016/j.compbiomed.2019.103396. Epub 2019 Aug 20.

Authors

Lianke Yao¹, Peng Li², Changchun Liu³, Yunxiu Hou⁴, Chang Yan¹, Liping Li⁵, Ke Li¹, Xinpei Wang¹, Aruna Deogire⁶, Chunlei Du⁷, Huan Zhang¹, Jikuo Wang¹, Han Li¹

Affiliations

¹ Institute of Biomedical Engineering, School of Control Science and Engineering, Shandong University, Jinan, Shandong, 250061, China.
² Institute of Biomedical Engineering, School of Control Science and Engineering, Shandong University, Jinan, Shandong, 250061, China; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. Electronic address: pli@sdu.edu.cn.
³ Institute of Biomedical Engineering, School of Control Science and Engineering, Shandong University, Jinan, Shandong, 250061, China. Electronic address: changchunliu@sdu.edu.cn.
⁴ Department of Health Management, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, China.
⁵ Department of Biomedical Engineering, School of Science and Technology, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250355, China.
⁶ Department of Instrumentation Engineering, A. C. Patil College of Engineering, Kharghar, Navi Mumbai, 410210, India.
⁷ Department of Cardiology, Jinan Forth People's Hospital, Jinan, Shandong, 250031, China.

PMID: 31446319
DOI: 10.1016/j.compbiomed.2019.103396

Abstract

Background: The significant association of myocardial ischemia with elevated QT interval variability (QTV) has been reported in myocardial infarction (MI) patients. However, the influence of the time course of MI on QTV has not been investigated systematically.

Method: Short-term QT and RR interval time series were constructed from the 5 min electrocardiograms of 49 coronary patients without MI and 26 patients with old MI (OMI). The QTV, heart rate variability (HRV), and QT-RR coupling of the two groups were analyzed using various time series analysis tools in the time- and frequency-domains, as well as nonlinear dynamics.

Results: Nearly all of the tested QTV indices for coronary patients with OMI were higher than those for patients without MI. However, no significant differences were found between the two groups in any of the variables employed to assess the HRV and QT-RR coupling. All of the markers that showed statistical significances in univariate analyses still possessed the capabilities of distinguishing between the two groups even after adjusting for studied baseline characteristics, including the coronary atherosclerotic burden.

Conclusions: The results suggested that the QTV increased in coronary patients with OMI compared to those without MI, which might reflect the influence of post-MI remodeling on the beat-to-beat temporal variability of ventricular repolarization. The non-significant differences in the HRV and QT-RR couplings could indicate that there were no differences in the modulation of the autonomic nervous system and interaction of QT with the RR intervals between the two groups.

Keywords: Coronary artery disease; Heart rate variability; Myocardial infarction; QT interval variability; Ventricular repolarization.

Publication types

Clinical Trial
Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Coronary Artery Disease / physiopathology*
Electrocardiography*
Female
Humans
Male
Middle Aged
Models, Cardiovascular*
Myocardial Infarction / physiopathology*
Signal Processing, Computer-Assisted*