The role of non-coding RNAs in neuroprotection and angiogenesis following ischemic stroke

Metab Brain Dis. 2020 Jan;35(1):31-43. doi: 10.1007/s11011-019-00485-2. Epub 2019 Aug 24.

Abstract

Stroke is the leading cause of death and physical disability worldwide. Non-coding RNAs (ncRNAs) are endogenous molecules that play key roles in the pathophysiology and retrieval processes following ischemic stroke. The potential of ncRNAs, especially microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in neuroprotection and angiogenesis highlights their potential as targets for therapeutic intervention. In this review, we document the miRNAs and lncRNAs that have been reported to exert regulatory actions in neuroprotective and angiogenic processes through different mechanisms involving their interaction with target coding genes. We believe that exploration of the expression profiles and the possible functions of ncRNAs during the recovery processes will help comprehension of the molecular mechanisms responsible for neuroprotection and angiogenesis, and may also contribute to find biomarkers and targets for future stroke intervention.

Keywords: Angiogenesis; Ischemic Stroke; Neuroprotection; Non-coding RNAs.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain Ischemia / genetics
  • Brain Ischemia / metabolism*
  • Brain Ischemia / prevention & control
  • Humans
  • Ischemic Stroke / genetics
  • Ischemic Stroke / metabolism*
  • Ischemic Stroke / prevention & control
  • Neovascularization, Physiologic / physiology*
  • Neuroprotection / physiology*
  • RNA, Untranslated / physiology*

Substances

  • RNA, Untranslated