Postprandial changes in gene expression of cholesterol influx and efflux mediators after intake of SFA compared with n-6 PUFA in subjects with and without familial hypercholesterolaemia: secondary outcomes of a randomised controlled trial

J Nutr Sci. 2019 Aug 13;8:e27. doi: 10.1017/jns.2019.25. eCollection 2019.


Keywords: CT, cycle threshold; FH, familial hypercholesterolaemia; Familial hypercholesterolaemia; Fat quality; Gene expression; LDL receptor; LDL-C, LDL-cholesterol; LDLR, LDL receptor; PBMC, peripheral blood mononuclear cells; Postprandial responses; SREBP, sterol regulatory element binding protein.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cholesterol / blood*
  • Fatty Acids / blood
  • Female
  • Gene Expression*
  • Homeostasis
  • Humans
  • Hyperlipoproteinemia Type II / complications*
  • Male
  • Postprandial Period*
  • Receptors, LDL / genetics*
  • Young Adult


  • Fatty Acids
  • Receptors, LDL
  • Cholesterol