Syringocystadenoma papilliferum associated with verrucous carcinoma of the skin in the same lesion: Report of four cases

J Cutan Pathol. 2020 Jan;47(1):12-16. doi: 10.1111/cup.13572. Epub 2019 Sep 4.


The association of syringocystadenoma papilliferum (SCAP) with verrucous carcinoma (VC) of the skin in the same lesion is a rare, but well-documented event. Although human papillomaviruses (HPV) have been proposed to have an etiologic role in the development of the verrucous proliferations associated with SCAP, most of the immunohistochemical and molecular studies have failed to show the presence of their genomic material in these lesions. We report a series of four cases of SCAP associated with VC in anogenital lesions. In two of the cases, we demonstrated the presence of the BRAF V600E mutation by polymerase chain reaction and immunohistochemistry, both in the glandular and in the squamous component. No HPV-related histopathologic changes were found, nor could the presence of viral DNA be showed.

Keywords: BRAF V600E mutation; human papillomaviruses; syringocystadenoma papilliferum; verrucous carcinoma of the skin.

Publication types

  • Case Reports
  • Clinical Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Amino Acid Substitution
  • Carcinoma, Verrucous* / genetics
  • Carcinoma, Verrucous* / metabolism
  • Carcinoma, Verrucous* / pathology
  • Humans
  • Male
  • Middle Aged
  • Mutation, Missense*
  • Neoplasms, Second Primary* / genetics
  • Neoplasms, Second Primary* / metabolism
  • Neoplasms, Second Primary* / pathology
  • Proto-Oncogene Proteins B-raf* / genetics
  • Proto-Oncogene Proteins B-raf* / metabolism
  • Sweat Gland Neoplasms* / genetics
  • Sweat Gland Neoplasms* / metabolism
  • Sweat Gland Neoplasms* / pathology
  • Tubular Sweat Gland Adenomas* / genetics
  • Tubular Sweat Gland Adenomas* / metabolism
  • Tubular Sweat Gland Adenomas* / pathology


  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf