Stem Cell Therapy: Curcumin Does the Trick

Phytother Res. 2019 Nov;33(11):2927-2937. doi: 10.1002/ptr.6482. Epub 2019 Aug 26.


Curcumin is a dietary polyphenol and a bioactive phytochemical agent that possesses anti-inflammatory, antioxidant, anticancer, and chemopreventive properties. Some of the predominant activities of stem cells include regeneration of identical cells and the ability to maintain the proliferation and multipotentiality. However, these cells could be stimulated to differentiate into specific cell types. Curcumin protects some stem cells from toxicity and can stimulate proliferation and differentiation of stem cells. In the present review, we summarize the antioxidant, stemness activity, antiaging, and neuroprotective as well as wound healing and regenerative effects of curcumin.

Keywords: curcumin; differentiation; stem cell.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Antioxidants / pharmacology
  • Cell Differentiation / drug effects
  • Cell Proliferation / drug effects
  • Cell- and Tissue-Based Therapy / methods*
  • Curcumin / pharmacology*
  • Humans
  • Regeneration / drug effects
  • Stem Cells / drug effects*
  • Stem Cells / physiology
  • Wound Healing / drug effects


  • Anti-Inflammatory Agents
  • Antioxidants
  • Curcumin