The Clinical Use of IgG Food Sensitivity Testing with Migraine Headache Patients: a Literature Review

Curr Pain Headache Rep. 2019 Aug 27;23(11):79. doi: 10.1007/s11916-019-0819-4.


Purpose of review: This literature review describes the relationship between IgG food sensitivities and their relation to migraine headaches.

Recent findings: IgG food sensitivities have been linked to various symptoms and disorders. While food sensitivities and intolerances are recognized within the clinical medicine community, diagnosing these sensitivities and intolerances can be challenging because symptoms are usually delayed hours to days and may not occur after every exposure to the allergen. Some reports indicate that foods such as chocolate, cheese, cow's milk, eggs, and red wine may be triggers for migraine headaches. The pathophysiology of migraine headaches is not well understood. Some evidence supports the use of IgG food sensitivity testing to determine food sensitivities and intolerances. IgG food sensitivity testing may prove to be a beneficial tool for healthcare practitioners, especially for patients experiencing migraine headache symptoms. Utilizing IgG food sensitivity testing to create customizable dietary recommendations for patients may allow healthcare providers to treat migraine headaches without the use of medications.

Keywords: Food sensitivities; Headaches; IgG; Migraine.

Publication types

  • Review

MeSH terms

  • Enzyme-Linked Immunosorbent Assay / methods
  • Food Hypersensitivity / complications*
  • Food Hypersensitivity / diagnosis*
  • Humans
  • Immunoglobulin G / blood*
  • Migraine Disorders / etiology*


  • Immunoglobulin G