Aloe vera as an herbal medicine in the treatment of metabolic syndrome: A review

Phytother Res. 2019 Oct;33(10):2649-2660. doi: 10.1002/ptr.6465. Epub 2019 Aug 28.


Metabolic syndrome (MS) is a highly prevalent health problem worldwide and is associated with different risk factors, including hyperglycemia, dyslipidemia, hypertension, and obesity. This condition increases the risk of developing type II diabetes mellitus and cardiovascular problems. The MS is one of the most important health concerns in industrialized countries and mainly results from a sedentary lifestyle, high levels of subjective stress, and unhealthy diets. Nowadays, the identification of appropriate health care approaches, such as herbal medicines, with fewer side effects is more favorable, especially with regard to the adverse effects of chemical drugs. Aloe barbadensis Miller known as Aloe vera is a useful plant with two major parts, including leaves that contain high concentrations of anthraquinone compounds and a clear gel. The gel is used as a food with several beneficial properties, such as antiinflammatory, antioxidant, antiviral, antibacterial, and wound-healing features. Other effects of A. vera, such as its lipid-lowering, antihypertensive, antidiabetic, antiobesity, and cardioprotective impacts, have been demonstrated in several studies. The present study was conducted to review the evidence on the pharmacological effects of A. vera on the different components of MS.

Keywords: Aloe barbadensis; Aloe vera; diabetes mellitus; dyslipidemia; hypertension; metabolic syndrome; obesity.

Publication types

  • Review

MeSH terms

  • Aloe* / chemistry
  • Herbal Medicine
  • Humans
  • Hypoglycemic Agents / pharmacology
  • Metabolic Syndrome / drug therapy*
  • Phytotherapy*
  • Plant Extracts / pharmacology*


  • Hypoglycemic Agents
  • Plant Extracts