Multicompartmental lipid-protein nanohybrids for combined tretinoin/herbal lung cancer therapy

Nanomedicine (Lond). 2019 Sep;14(18):2461-2479. doi: 10.2217/nnm-2019-0090. Epub 2019 Aug 28.

Abstract

Aim: Multicompartmental lipid-protein nanohybrids (MLPNs) were developed for combined delivery of the anticancer drugs tretinoin (TRE) and genistein (GEN) as synergistic therapy of lung cancer. Materials & methods: The GEN-loaded lipid core was first prepared and then coated with TRE-loaded zein shell via nanoprecipitation. Results: TRE/GEN-MLPNs demonstrated a size of 154.5 nm. In situ ion pair formation between anionic TRE and the cationic stearyl amine improved the drug encapsulation with enhanced stability of MLPNs. TRE/GEN-coloaded MLPNs were more cytotoxic against A549 cancer cells compared with combined free GEN/TRE. In vivo, lung cancer bearing mice treated with TRE/GEN-MLPNs displayed higher apoptotic caspase activation compared with mice-treated free combined GEN/TRE. Conclusion: TRE/GEN-MLPNs might serve as a promising parenteral nanovehicles for lung cancer therapy.

Keywords: genistein; lipid–protein nanohybrids; lung cancer; multicompartmental nanoparticles; tretinoin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • A549 Cells
  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / therapeutic use
  • Drug Synergism
  • Genistein / administration & dosage*
  • Genistein / pharmacokinetics
  • Genistein / therapeutic use
  • Humans
  • Lipids / chemistry*
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / pathology
  • Mice
  • Nanocapsules / chemistry*
  • Tretinoin / administration & dosage*
  • Tretinoin / pharmacokinetics
  • Tretinoin / therapeutic use
  • Zein / chemistry

Substances

  • Antineoplastic Agents
  • Lipids
  • Nanocapsules
  • Tretinoin
  • Zein
  • Genistein