Laminin: molecular organization and biological function

J Oral Pathol. 1988 Aug;17(7):309-23. doi: 10.1111/j.1600-0714.1988.tb01543.x.

Abstract

Laminin, the most abundant glycoprotein molecule found in basement membrane, has multiple functions in eukaryotic tissues. It serves to attach epithelial cells to basement membrane, aids development and migration of specific cell types in growth and maturation, and has been implicated in tumor metastasis and some types of infection. Current concepts of the molecular organization and myriad functions of the laminin molecule are reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacterial Adhesion
  • Biology
  • Biomarkers, Tumor
  • Cell Physiological Phenomena
  • Laminin / physiology*
  • Laminin / therapeutic use
  • Protein Conformation
  • Wound Healing

Substances

  • Biomarkers, Tumor
  • Laminin