The PHD finger of Spp1 mediates histone modification cross-talk

Catherine A Musselman; Tatiana G Kutateladze

doi:10.1042/BCJ20190492

The PHD finger of Spp1 mediates histone modification cross-talk

Biochem J. 2019 Aug 28;476(16):2351-2354. doi: 10.1042/BCJ20190492.

Authors

Catherine A Musselman¹, Tatiana G Kutateladze²

Affiliations

¹ Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045, U.S.A. tatiana.kutateladze@cuanschutz.edu catherine.musselman@cuanschutz.edu.
² Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, U.S.A. tatiana.kutateladze@cuanschutz.edu catherine.musselman@cuanschutz.edu.

Abstract

Binding of the Spp1 PHD finger to histone H3K4me3 is sensitive to adjacent post-translational modifications in the histone tail. This commentary discusses the findings of He and colleagues [Biochem. J.476, 1957-1973] which show that the PHD finger binds to H3K4me3 in a selective manner which is conserved in the Saccharomyces pombe and mammalian orthologues of Spp1.

Keywords: PHD finger; chromatin; epigenetic; histone.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Histone Code
Histones*
Models, Molecular
PHD Zinc Fingers*
Protein Binding
Protein Processing, Post-Translational

Substances

Histones
histone H3 trimethyl Lys4

Grants and funding

R35 GM128705/GM/NIGMS NIH HHS/United States