The discovery of the G-spot and verification of its anatomy and histology paved the way to better understanding. Until 2012, the G-spot was defined as a physiological sexual response phenomenon with no identifiable anatomical correlate. The weakness of this definition is that a physiological response cannot exist without an anatomical basis, so the question motivating the present study was formulated: Are current scientific-clinical data sufficient to resolve the controversy about the anatomical existence of a G-spot? It is important to stipulate that no systematic review of the G-spot has hitherto been published. Manual and electronic searches revealed postmortem and in vivo studies describing the G-spot and findings reported within PRISMA-IPD guidelines. The objective of the present review was to provide evidence-based information related to the G-spot. Articles were quality-assessed using validated instruments. Publications on the G-spot from 1950 to May 2019 were reviewed. Of the 279 full-text articles examined, 30 met the eligibility criteria. The findings indicate that there are reliable scientific-clinical data to support the existence of an anatomical G-spot structure. Transient anterior-distal vaginal wall engorgement is caused by blood entrapment within the G-spot structure. Histological examination effectively ruled out the G-spot as the organ cannot be responsible for female ejaculation since no glandular tissue was identifiable. Finally, the results of this study could assist in developing new therapeutic, surgical interventions to treat secondary G-spot dysfunction. Additionally, this review indicates ample opportunities for further scientific-clinical investigations and has thereby moved the field forward. Clin. Anat. 32:1094-1101, 2019. © 2019 Wiley Periodicals, Inc.
Keywords: G-spot; G-spot MRI; G-spot anatomy; G-spot histology; G-spotplasty.
© 2019 Wiley Periodicals, Inc.