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. 2019 Oct;58-59:49-54.
doi: 10.1016/j.gde.2019.07.011. Epub 2019 Aug 26.

Gene Conversion Generates Evolutionary Novelty That Fuels Genetic Conflicts

Free PMC article

Gene Conversion Generates Evolutionary Novelty That Fuels Genetic Conflicts

Matthew D Daugherty et al. Curr Opin Genet Dev. .
Free PMC article


Genetic conflicts arise when the evolutionary interests of two genetic elements are not aligned. Conflicts between genomes (e.g. pathogen versus host) or within the same genome (e.g. internal parasitic DNA sequences versus the rest of the host genome) can both foster 'molecular arms races', in which genes on both sides of the conflict rapidly evolve due to bouts of adaptation and counter-adaptation. Importantly, a source of genetic novelty is needed to fuel these arms races. In this review, we highlight gene conversion as a major force in generating the novel alleles on which selection can act. Using examples from both intergenomic and intragenomic conflicts, we feature the mechanisms by which gene conversion facilitates the rapid evolution of genes in conflict.

Conflict of interest statement

Conflict of Interest: SEZ is an inventor on a patent application based on wtf killers (patent application serial 62/491,107). MDD declares no conflict of interest.

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