Lymphomatoid Papulosis and Other Lymphoma-Like Diseases

Adrian Moy; James Sun; Sophia Ma; Lucia Seminario-Vidal

doi:10.1016/j.det.2019.05.005

Lymphomatoid Papulosis and Other Lymphoma-Like Diseases

Dermatol Clin. 2019 Oct;37(4):471-482. doi: 10.1016/j.det.2019.05.005. Epub 2019 Aug 6.

Authors

Adrian Moy¹, James Sun², Sophia Ma¹, Lucia Seminario-Vidal³

Affiliations

¹ Department of Dermatology and Cutaneous Surgery, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA.
² Department of Cutaneous Oncology, Moffitt Cancer Center, 10920 McKinley Drive, Tampa, FL 33612, USA.
³ Department of Dermatology and Cutaneous Surgery, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA. Electronic address: luciasem@health.usf.edu.

PMID: 31466587
DOI: 10.1016/j.det.2019.05.005

Abstract

Pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica are the 2 main subtypes of pityriasis lichenoides. They represent the acute and chronic forms of the disease; both may have clonal T cells. Several treatment modalities are used, but it has been difficult to determine efficacy because of the possibility of spontaneous remission. Cutaneous CD30+ lymphoproliferative disorders constitute many cutaneous T-cell lymphomas and comprise lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma (ALCL). Both have an excellent prognosis. Lymphomatoid papulosis often only requires observation or treatment of symptoms. First-line therapies for primary cutaneous ALCL are surgical excision or radiotherapy.

Keywords: Anaplastic large cell lymphoma; CD30 lymphoproliferative disorder; Lymphomatoid papulosis; Pityriasis lichenoides chronica; Pityriasis lichenoides et varioliformis acuta.

Publication types

Review

MeSH terms

Adrenal Cortex Hormones / therapeutic use
Anti-Bacterial Agents / therapeutic use
Antibodies, Monoclonal / therapeutic use
Antineoplastic Agents / therapeutic use
Dermatologic Surgical Procedures
Humans
Immunosuppressive Agents / therapeutic use
Keratolytic Agents / therapeutic use
Ki-1 Antigen
Lymphoma, Primary Cutaneous Anaplastic Large Cell / diagnosis
Lymphoma, Primary Cutaneous Anaplastic Large Cell / pathology
Lymphoma, Primary Cutaneous Anaplastic Large Cell / therapy*
Lymphomatoid Papulosis / diagnosis
Lymphomatoid Papulosis / pathology
Lymphomatoid Papulosis / therapy*
Phototherapy
Pityriasis Lichenoides / diagnosis
Pityriasis Lichenoides / pathology
Pityriasis Lichenoides / therapy*
Radiotherapy
Skin Neoplasms / diagnosis
Skin Neoplasms / pathology
Skin Neoplasms / therapy*

Substances

Adrenal Cortex Hormones
Anti-Bacterial Agents
Antibodies, Monoclonal
Antineoplastic Agents
Immunosuppressive Agents
Keratolytic Agents
Ki-1 Antigen
SGN-30 monoclonal antibody