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. 2019 Oct;37(4):607-613.
doi: 10.1016/j.det.2019.05.016. Epub 2019 Jul 30.

Hereditary Tumor Syndromes With Skin Involvement


Hereditary Tumor Syndromes With Skin Involvement

Ramiz N Hamid et al. Dermatol Clin. .


Cutaneous findings that appear in childhood may be the first sign of a hereditary tumor syndrome. Early detection of genodermatoses allows the patient and at-risk family members to be screened for associated malignancies. This article provides a brief description of the pathogenesis and clinical manifestations of various inherited disorders with skin involvement, along with treatment updates. Advances in molecular-based therapy have spurred development of novel treatment methods for various genodermatoses such as xeroderma pigmentosum (XP) and Gorlin-Goltz syndrome. Further studies are needed to better assess the efficacy of many of these new treatment options.

Keywords: Genodermatoses; Gorlin-Goltz syndrome; Hereditary tumor syndrome; Xeroderma pigmentosum.

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