Innate Immunity

Pediatr Clin North Am. 2019 Oct;66(5):905-911. doi: 10.1016/j.pcl.2019.06.011.


The innate immune response system forms an important line of defense by deploying a limited number of receptors specific for conserved microbial components. This deployment generates a rapid inflammatory response, while activating the adaptive immune system. Improvements in our understanding of the innate immune system have allowed us to explore various therapeutic strategies via modulation of the immune response.

Keywords: Anatomic barriers; Immune modulation; Inflammatory response; Innate immunity; Microbial defense; Physiologic barriers.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibody Formation / immunology
  • Humans
  • Hypersensitivity / immunology
  • Immunity, Innate / immunology*
  • Infections / immunology
  • Inflammation / immunology
  • Toll-Like Receptors / immunology


  • Toll-Like Receptors