Diagnosis and Management of Food Allergy

Roxanne Carbonell Oriel; Julie Wang

doi:10.1016/j.pcl.2019.06.002

Diagnosis and Management of Food Allergy

Pediatr Clin North Am. 2019 Oct;66(5):941-954. doi: 10.1016/j.pcl.2019.06.002. Epub 2019 Aug 5.

Authors

Roxanne Carbonell Oriel¹, Julie Wang²

Affiliations

¹ Department of Pediatrics, Division of Allergy & Immunology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1198, New York, NY 10029, USA.
² Department of Pediatrics, Division of Allergy & Immunology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1198, New York, NY 10029, USA. Electronic address: julie.wang@mssm.edu.

PMID: 31466683
DOI: 10.1016/j.pcl.2019.06.002

Abstract

Food allergy is an immune-mediated disease and must be differentiated from other adverse effects related to food that are non-immune mediated. Symptoms of immunoglobulin (Ig) E-mediated allergy can range from mild to severe, and life-threatening anaphylaxis may occur. Current recommended strategies for diagnosis include the use of skin prick tests, allergen-specific serum IgE, and/or oral food challenges. Management entails allergen avoidance and appropriate treatment of allergic reactions should accidental ingestions occur. Treatment approaches under investigation include immunotherapy as well as biologics and novel vaccines. Attention has also recently focused on implementing strategies for prevention of food allergy.

Keywords: Allergen-specific serum IgE; Anaphylaxis; Diagnosis; Disease management; Food allergy; Oral food challenge; Prevention; Skin prick test.

Publication types

Review

MeSH terms

Administration, Oral
Allergens / immunology
Desensitization, Immunologic / methods*
Food Hypersensitivity / diagnosis*
Food Hypersensitivity / immunology
Food Hypersensitivity / physiopathology
Food Hypersensitivity / therapy*
Humans
Immunoglobulin E / immunology
Skin Tests

Substances

Allergens
Immunoglobulin E