Monoclonal antibodies defining distinctive human T cell surface antigens

Science. 1979 Oct 19;206(4416):347-9. doi: 10.1126/science.314668.

Abstract

Three novel nonoclonal antibodies (designed OKT1, OKT3, and OKT4) were generated against surface determinants of human peripheral T cells. Both OKT1 and OKT3 reacted with all human peripheral T cells and 5 to 10 percent of thymocytes but differed in their reactivities with T cel- lines. By contrast, OKT4 reacted with 55 percent of human peripheral T cells and 80 percent of thymocyted in that they did not react with normal B cells, null cells, monocytes, or granulocytes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibody Specificity
  • Antigens, Surface / analysis*
  • Cells, Cultured / immunology
  • Clone Cells / immunology
  • Humans
  • Leukemia, Experimental / immunology
  • Mice
  • Plasmacytoma / immunology
  • T-Lymphocytes / immunology*

Substances

  • Antigens, Surface