Xyloglucan, hibiscus and propolis to reduce symptoms and antibiotics use in recurrent UTIs: a prospective study

Future Microbiol. 2019 Aug:14:1013-1021. doi: 10.2217/fmb-2019-0145.


Aim: To evaluate the efficacy of a medical device containing xyloglucan, hibiscus and propolis in the management of recurrent urinary tract infections (rUTIs). Patients & methods: Sixty-one women affected by rUTIs received this medical device, one capsule a day for 15 days (one cycle every month, for 6 months), in an observational, prospective study. Clinical and microbiological evaluations were performed at baseline and 1, 3 and 6 months from enrolment. Results: At first follow-up, 41 reported a clinical improvement and a return to their clinical status before UTI, while 47 and 51 did so at the second and third follow-up evaluations. A statistically significant clinical improvement was reported at each follow-up visit (quality of life [QoL] 94.2 vs 98.6; QoL 94.1 vs 98.7; QoL 94.2 vs 99.1; p < 0.001). A statistically significant reduction in antibiotic use was reported. Conclusion: This medical device is able to improve quality of life in women with rUTIs, reduce recurrences and antibiotic use.

Keywords: antibiotic stewardship; ibiscus; propolis; quality of life; urinary tract infections; xyloglucan.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Anti-Infective Agents / administration & dosage*
  • Female
  • Glucans / administration & dosage*
  • Hibiscus / chemistry
  • Humans
  • Middle Aged
  • Plant Extracts / administration & dosage*
  • Propolis / administration & dosage*
  • Prospective Studies
  • Secondary Prevention
  • Treatment Outcome
  • Urinary Tract Infections / drug therapy*
  • Urinary Tract Infections / prevention & control
  • Xylans / administration & dosage*
  • Young Adult


  • Anti-Infective Agents
  • Glucans
  • Plant Extracts
  • Xylans
  • xyloglucan
  • Propolis