Effect of phytic acid on postprandial serum uric acid level in healthy volunteers: a randomized, double-blind, crossover study

Nucleosides Nucleotides Nucleic Acids. 2020;39(4):504-517. doi: 10.1080/15257770.2019.1656337. Epub 2019 Aug 30.


Phytic acid, a constituent of various plants, has been related to health benefits. Phytic acid has been shown to inhibit purine nucleotide metabolism in vitro and suppress elevation of plasma uric acid levels after purine administration in animal models. This study investigated the effect of phytic acid on postprandial serum uric acid (SUA) in humans. This randomized, double-blind, crossover design study included 48 healthy subjects with normal fasting SUA. Subjects consumed a control drink and a phytic acid drink with purine-rich food, and serum and urine uric acid levels were measured for 360 min after purine loading. Phytic acid lowered the incremental area under the curve (0-360 min) and incremental maximum concentration of SUA after purine loading (p < 0.05); tended to lower cumulative urinary uric acid excretion (0-360 min) after purine loading (p < 0.10); and suppressed postprandial SUA in this clinical study. Altogether, our findings suggest that phytic acid may play a beneficial role in controlling postprandial SUA.

Keywords: Phytic acid; hyperuricemia; purine; serum uric acid.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Cross-Over Studies
  • Double-Blind Method
  • Female
  • Healthy Volunteers
  • Humans
  • Male
  • Middle Aged
  • Phytic Acid / administration & dosage
  • Phytic Acid / blood*
  • Purines / administration & dosage
  • Purines / blood
  • Uric Acid / blood*
  • Young Adult


  • Purines
  • Uric Acid
  • Phytic Acid
  • purine