The stepwise photodamage of organelles by two-photon luminescent ruthenium(ii) photosensitizers

Chem Commun (Camb). 2019 Sep 17;55(75):11235-11238. doi: 10.1039/c9cc05962h.

Abstract

Ru(ii) polypyridyl complexes, containing a morpholine moiety, and possessing two-photon absorption properties and pH dependent singlet oxygen production were used for stepwise lysosomes-to-mitochondria photodamage of cancer cells.

MeSH terms

  • A549 Cells
  • Cell Survival / drug effects
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology*
  • Humans
  • Hydrogen-Ion Concentration
  • Light*
  • Microscopy, Confocal
  • Molecular Structure
  • Optical Imaging
  • Organelles / chemistry*
  • Photochemotherapy*
  • Photons*
  • Photosensitizing Agents / chemical synthesis
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / pharmacology*
  • Ruthenium / chemistry
  • Ruthenium / pharmacology*

Substances

  • Coordination Complexes
  • Photosensitizing Agents
  • Ruthenium