Prediction of the depth of invasion in superficial pharyngeal cancer: Microvessel morphological evaluation with narrowband imaging

Head Neck. 2019 Nov;41(11):3970-3975. doi: 10.1002/hed.25935. Epub 2019 Aug 30.

Abstract

Background: Magnifying endoscopy with narrowband imaging (ME-NBI) is useful in predicting the invasion depth by examining the microvascular status of tumor surfaces. This retrospective study aimed to determine its efficacy in pharyngeal cancer.

Methods: Between April 2016 and March 2018, 59 lesions from 46 patients who underwent transoral resection were retrospectively analyzed. Using ME-NBI, microvascular status was classified into B1, B2, or B3, based on the classification of the Japan Esophageal Society.

Results: A significant correlation was observed between microvascular status and invasion depth (P = .011). Mean thickness of lesions with B1, B2, and B3 vessels were 563, 1364, and 2825 μm, respectively (P = .006). In previously treated lesions, a significant correlation was observed between microvascular status and invasion depth (P = .012).

Conclusions: ME-NBI is useful in predicting the invasion depth and thickness of pharyngeal tumors, even in patients with previously treated lesions.

Keywords: ELPS; microvessel morphology; narrowband imaging; superficial carcinoma; transoral surgery.

MeSH terms

  • Aged
  • Endoscopy*
  • Epithelium / diagnostic imaging
  • Epithelium / pathology
  • Female
  • Humans
  • Male
  • Microvessels / diagnostic imaging*
  • Microvessels / pathology*
  • Middle Aged
  • Mucous Membrane / diagnostic imaging
  • Mucous Membrane / pathology
  • Narrow Band Imaging*
  • Neoplasm Invasiveness
  • Pharyngeal Neoplasms / diagnostic imaging*
  • Pharyngeal Neoplasms / pathology*
  • Predictive Value of Tests
  • Retrospective Studies