Lead bioactive compounds of Aloe vera as potential anticancer agent

Pharmacol Res. 2019 Oct:148:104416. doi: 10.1016/j.phrs.2019.104416. Epub 2019 Aug 27.


Aloe vera (Aloe barbadensis Miller) is a perennial succulent medicinal plant. It has been used as a traditional or folk medicine for thousands of years and claimed that it possesses wound and burn healing activities, and anti-inflammatory as well as immunomodulatory effects. In recent years, the use of Aloe vera has been growing as a dietary supplement. The pre-clinical studies over the last couple of decades uncover the potential therapeutic activities of Aloe vera and its bioactive compounds, especially against neoplastic disease. Such investigations indicate the possible preventive as well as therapeutic effects of Aloe vera against cancer. Here, we discuss the crucial bioactive compounds of Aloe vera that have been harnessed against cancer and also address several mechanisms of action of these lead bioactive compounds compared to other standard drugs involved in cancer prevention and treatment.

Keywords: Aloe vera; Cancer; Lead bioactive compounds; Prevention; Treatment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aloe / chemistry*
  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use*
  • Burns / drug therapy
  • Humans
  • Neoplasms / drug therapy*
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use*
  • Plants, Medicinal / chemistry
  • Wound Healing / drug effects


  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Plant Extracts